= Creation = == How Science is Reinventing Life Itself == === Adam Rutherford Wiley 2013 Cedar Mill Lib. 576.83 Rutherford === ------- .p136 "What I cannot create, I do not understand" Richard Feynman 1988 .p139 Synthia Craig Venter $40M 15 years 582K base pairs 517 genes ... 4.6M E. coli, 3G human .p145 Freckles the goat, spider silk proteins in milk (stronger than Kevlar? no) .p151 restriction enzymes cut DNA at specific code groups 1968 Hamilton Smith .p159 Amyris 2011 goal 200 million liters farnesene diesel from yeast from brazilian surgar, fail .p166 Ron Weiss - Sniper "circuit" virus inserts code to kill !HeLa cancer cells if 5 triggers activated .p176 David Loftus - Cytokines for radiation protection in space - vague .p184 music sampling analogy .p185 Registry of Standard Biological Parts - !BioBricks Drew Endy @ Stanford, Tom Knight @ MIT, Christopher Voigt @ UCSF .p186 iGEM International Genetically Engineered Machine competition .p195 BRCA1 BRCA2 "owned" by Myriad Genetics and the University of Utah Research Foundation .p197 2012 April Obama National Bioeconomy Blueprint .p203 "Take Flour Back" in UK, Rothamsted EβF scares off aphids .p206 1975 Asilomar Conference Paul Berg .p208 Paul Ehrlich (ex- Friends of the Earth) ''"the potential benefits from recombinant DNA research are so great that it would be foolhardy to restrict such research on the basis of imaginary risks"'' .p213 Yoshihiro Kawaoka, U-Wisc ''Nature'', and Ron Fouchier, Erasmus Med Center Rotterdam ''Science'' - ferret flu expeirments .p218 Gilles-Eric Seralini used tumor-prone rats to "prove" GM maize caused cancer, poorly designed experiment .p222 Artemisinin from wormwood for malaria .p236 Steve Benner (Westheimer Inst) 2011 two alien bases "Z and P" in DNA .p238 XNA xeno-nucleic acids, deoxyribose -> arabinose (ANA) -> threoose (TNA), FANA and CeNA .p240 aptamer, strands of DNA or RNA designed to fold and clasp onto a very specific target, XNA invisible to nucleases .p243 UAG triplet is amber stop (one of 3), Jason Chin uses sequence for new tRNA pairing .p246 frozen Greenland mud cores 800 KYa extracted viable DNA