Creation

How Science is Reinventing Life Itself

Adam Rutherford Wiley 2013 Cedar Mill Lib. 576.83 Rutherford

• p136 "What I cannot create, I do not understand" Richard Feynman 1988
• p139 Synthia Craig Venter $40M 15 years 582K base pairs 517 genes ... 4.6M E. coli, 3G human
• p145 Freckles the goat, spider silk proteins in milk (stronger than Kevlar? no)
• p151 restriction enzymes cut DNA at specific code groups 1968 Hamilton Smith
• p159 Amyris 2011 goal 200 million liters farnesene diesel from yeast from brazilian surgar, fail

• p166 Ron Weiss - Sniper "circuit" virus inserts code to kill HeLa cancer cells if 5 triggers activated

• p176 David Loftus - Cytokines for radiation protection in space - vague
• p184 music sampling analogy

• p185 Registry of Standard Biological Parts - BioBricks Drew Endy @ Stanford, Tom Knight @ MIT, Christopher Voigt @ UCSF

• p186 iGEM International Genetically Engineered Machine competition
• p195 BRCA1 BRCA2 "owned" by Myriad Genetics and the University of Utah Research Foundation
• p197 2012 April Obama National Bioeconomy Blueprint

• p203 "Take Flour Back" in UK, Rothamsted EβF scares off aphids

• p206 1975 Asilomar Conference Paul Berg

• p208 Paul Ehrlich (ex- Friends of the Earth) "the potential benefits from recombinant DNA research are so great that it would be foolhardy to restrict such research on the basis of imaginary risks"

• p213 Yoshihiro Kawaoka, U-Wisc Nature, and Ron Fouchier, Erasmus Med Center Rotterdam Science - ferret flu expeirments

• p218 Gilles-Eric Seralini used tumor-prone rats to "prove" GM maize caused cancer, poorly designed experiment
• p222 Artemisinin from wormwood for malaria
• p236 Steve Benner (Westheimer Inst) 2011 two alien bases "Z and P" in DNA

• p238 XNA xeno-nucleic acids, deoxyribose -> arabinose (ANA) -> threoose (TNA), FANA and CeNA

• p240 aptamer, strands of DNA or RNA designed to fold and clasp onto a very specific target, XNA invisible to nucleases
• p243 UAG triplet is amber stop (one of 3), Jason Chin uses sequence for new tRNA pairing
• p246 frozen Greenland mud cores 800 KYa extracted viable DNA